Non-opioid analgesic poisoning
نویسندگان
چکیده
منابع مشابه
Non-opioid analgesic poisoning.
Since the first cases of severe and fatal liver damage were reported in 1966,1,2 overdose of paracetamol has become the cause of 100–200 deaths in the UK each year.3 Paracetamol toxicity remains the leading cause of fulminant hepatic failure in the UK and is a common reason for liver transplantation.4,5 Knowledge of the toxic mechanism (Fig 1) has led to effective antidotes which provide substr...
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Copyright © 2012 Massachusetts Medical Society. Opioid analgesic overdose is a preventable and potentially lethal condition that results from prescribing practices, inadequate understanding on the patient’s part of the risks of medication misuse, errors in drug administration, and pharmaceutical abuse.1,2 Three features are key to an understanding of opioid analgesic toxicity. First, opioid ana...
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Compound trans-4-(p-bromophenyl)-4-(dimethylamino)-1-(2-thiophen-2-yl-ethyl)-cyclohexanol (C8813), structurally unrelated to morphine, is a novel analgesic. The present study examined the antinociception, opioid receptor selectivity and in vitro activity of C8813. The antinociceptive activity was evaluated using mouse hot plate and acetic acid writhing tests. In mouse hot plate test, the antino...
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Editor’s Note: This editorial by Dr. Peggy Compton, and the three papers in this issue by Drs. Webster, Fishbain, Zacny, and their colleagues, initiate the Opioids, Substance Abuse & Addiction Section of Pain Medicine. Under the leadership of section co-editors Steve Passik, PhD, and Lynn Webster, MD, PhD, and their distinguished colleagues, this section will inform our readership about this cr...
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INTRODUCTION Traditionally, opioids have been the cornerstone of therapy for patients suffering from cancer pain, regardless of the potential to develop opioid tolerance. In chronic pain patients who experience worsening pain despite increasing doses of opioids, the clinical role of opioid-induced hyperalgesia is gaining more recognition. CASE Presented here is the case of a 56-year-old man w...
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ژورنال
عنوان ژورنال: Clinical Medicine
سال: 2003
ISSN: 1470-2118,1473-4893
DOI: 10.7861/clinmedicine.3-2-119